Fast and accurate haplotype frequency estimation for large haplotype vectors from pooled DNA data
نویسندگان
چکیده
منابع مشابه
Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA.
The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of these estimates, and show that pooling DNA samples is efficient in estimating haplotype frequenc...
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MOTIVATION A variety of hypotheses have been proposed for finding the missing heritability of complex diseases in genome-wide association studies. Studies have focused on the value of haplotype to improve the power of detecting associations with disease. To facilitate haplotype-based association analysis, it is necessary to accurately estimate haplotype frequencies of pooled samples. RESULTS ...
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Structural rearrangements, including copy-number alterations and inversions, are increasingly recognized as an important contributor to human genetic variation. Copy number variants are readily measured via array-based techniques like comparative genomic hybridization, but copy-neutral variants such as inversion polymorphisms remain difficult to identify without whole genome sequencing. We intr...
متن کاملA fast haplotype inference method for large population genotype data
With the rapid progress of genotyping techniques, many large-scale, genome-wide disease studies are now under way. One of the challenges of large disease-association studies is developing a fast and accurate computing method for haplotype inference from genotype data. In this paper, a new computing method for population-based haplotype inference problem is proposed. The designed method does not...
متن کاملEstimating Haplotype Frequencies from Genotypes of Pooled DNA
Estimating Haplotype Frequencies from Genotypes of Pooled DNA
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2012
ISSN: 1471-2156
DOI: 10.1186/1471-2156-13-94